Image-based ocular proton therapy
This thesis investigates how magnetic resonance imaging can improve planning and evaluation of proton beam therapy for uveal melanoma, showing that high-resolution ocular MRI provides geometrically accurate images for treatment planning and enables reliable tumor measurements, with improved accuracy over ultrasound in anterior tumors. The work demonstrates that commonly used tumor models overestimate tumor size and volume, whereas MRI-based three-dimensional delineations provide more precise patient-specific characterization. Quantitative and clinical MRI approaches, including perfusion- and diffusion-weighted imaging, are evaluated for response monitoring and indicate that simpler clinically applicable methods are sufficiently reproducible. The thesis proposes an MRI-based workflow that can eliminate invasive marker placement, with potential gains in treatment accuracy and efficiency.
Lisa Klaassen (April 2026)
Peer reviewed publications that are part of this manuscript:
- Magnetic Resonance Imaging in the Clinical Care for Uveal Melanoma Patients—A Systematic Review from an Ophthalmic Perspective
Cancers (2023) - Geometrical accuracy of magnetic resonance imaging for ocular proton therapy planning
Physics and Imaging in Radiation Oncology (2024) - Automatic Three-Dimensional Magnetic Resonance-based measurements of tumour prominence and basal diameter for treatment planning of uveal melanoma
Physics and Imaging in Radiation Oncology (2022) - Estimating uveal melanoma volume with ellipsoid tumour models
Acta Ophthalmologica (2025) - Quantitative Perfusion-Weighted Magnetic Resonance Imaging in Uveal Melanoma
Investigative Ophthalmology & Visual Science (2024)
