Function and structure of the eye muscles in myasthenia
This thesis examines structural and functional abnormalities of extraocular muscles in myasthenia gravis using quantitative MRI. Advanced imaging approaches are used to characterize muscle composition, contractile behavior, and fatigue-related functional impairment. The findings identify disease-associated imaging signatures that correlate with clinical manifestations such as ptosis and ophthalmoparesis. The work proposes MRI-derived biomarkers to improve diagnosis, phenotyping, and longitudinal monitoring in neuromuscular ophthalmology.
Kevin Keene (September 2023)
Peer reviewed publications that are part of this manuscript:
- Clinical and imaging clues to the diagnosis and follow‐up of ptosis and ophthalmoparesis
Journal of Cachexia, Sarcopenia and Muscle (2022) - Diagnosing myasthenia gravis using orthoptic measurements: assessing extraocular muscle fatiguability
Journal of Neurology, Neurosurgery & Psychiatry (2023) - T2 relaxation‐time mapping in healthy and diseased skeletal muscle using extended phase graph algorithms
Magnetic Resonance in Medicine (2020) - The feasibility of quantitative MRI of extra‐ocular muscles in myasthenia gravis and Graves' orbitopathy
NMR in Biomedicine (2021) - Eye Muscle MRI in Myasthenia Gravis and Other Neuromuscular Disorders
Journal of Neuromuscular Diseases (2023)
