MRI for planning and characterization of uveal melanoma patients treated with proton beam therapy
This thesis develops MRI-based methods for treatment planning and longitudinal characterization of uveal melanoma in proton beam therapy. It combines anatomical, quantitative, and dynamic contrast-enhanced MRI to assess tumor morphology and perfusion before and after treatment. The results demonstrate that MRI enables accurate tumor measurements and clinically relevant follow-up, including in challenging post-intervention settings. The work establishes MRI biomarkers that support personalized planning and response assessment in ocular oncology.
Myriam Jaarsma-Coes (February 2023)
Peer reviewed publications that are part of this manuscript:
- Measuring eye deformation between planning and proton beam therapy position using magnetic resonance imaging
Physics and Imaging in Radiation Oncology (2020) - Inter-Observer Variability in MR-Based Target Volume Delineation of Uveal Melanoma
Advances in Radiation Oncology (2023) - Comparison of Magnetic Resonance Imaging–Based and Conventional Measurements for Proton Beam Therapy of Uveal Melanoma
Ophthalmology Retina (2023) - MRI enables accurate diagnosis and follow-up in uveal melanoma patients after vitrectomy
Melanoma Research (2019) - Eye-specific quantitative dynamic contrast-enhanced MRI analysis for patients with intraocular masses
Magnetic Resonance Materials in Physics, Biology and Medicine (2022)